The winter storm in the third excerpt must to have taken place during the expedition against Bulgaria, which Theodore II Laskaris carried out in 1254-1256, and in particular during the winter of 1254, where he attempted to occupy the fortress Tsepina in Rhodope mountains. The metaphors ΄ἴνδαλμα’, ‘μὴ, ὄν’ and ‘στέρησις’ has to be interpreted as a reference to the decline and weakening of Bulgaria after the death of tsar John Asen II, the Theodore’s father -in-law. The epithet «πορνική» for the Bulgarian kingdom has to be connected with the violation of the treaty between Nicea and Bulgaria by Michael Asen, as well as with the attempt of the Bulgarian tsar to associate himself with the Theodore’s rival, Michael Palaeologus, through a marriage between the last and the Michael Asen’s sister. The reference to the mother and the daughter-in-law is actually a metaphor for the Eastern and the Western provinces of the Empire of Nicea, which is supported by a similar expression in one another letter of Theodore II. The identity of the emperor enables the right interpretation of the fragments’ content. The basic argument for the identification is the use of form of the verb ΄ἐκστροβέω΄, which occurs according to TLG only in texts of the learned emperor. Paramelle in 1979, with an unknown and unpublished letter of emperor Theodore II Laskaris, which can be dated very likely in 1254. Suppl.1202, published for the first time by J. The paper identifies the excerpts from Cod. Apart from that, the author rises an important question of the employment of Skoutariotes' Chronicle by later historians. The additional details provided by Skoutariotes are corroborated with the information we find in other surviving sources, a fact which gives his testimony much more significance than previously believed. The differences in the accounts of the two writers can be explained by Skoutariotes' employment of other sources, unknown to us today, and also by the fact that he included his eye-witness account in the Chronicle he compiled. In respect to Michael VIII, however, Skoutariotes tended to mitigate the excessive commendation of Akropolites by omitting certain epithets, or, by a careful word play that sometimes resulted in completely opposite statements compared with the ones we find in Akropolites. Skoutariotes expressed positive attitude towards the Laskarids in the praises of their imperial virtues. The greatest divergence from the text of Akropolites is in the portrayal of the Laskarid emperors and the first Palaiologos, Michael VIII. The Chronicle of Theodore Skoutariotes relies on the historical work of George Akropolites to a great extent, although significant additions to or omissions from Akropolites' narrative can be noticed. We found 75 risk loci, of which 42 were new at the time of analysis.This paper deals with the differences between the texts of the two main sources for the 13 th-century Byzantine history-Χρονικx συγγραφή of George Akropolites and Σύνοψις χρονική of Theodore Skoutariotes-who give an account of the events from 1204 to 1261. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. EADB DEGESCO EADI GERAD Demgene FinnGen ADGC CHARGE Lindsay A FarrerĬharacterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes.
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